[HTML][HTML] Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the …

D Vigetti, A Genasetti, E Karousou, M Viola… - Journal of biological …, 2010 - ASBMB
Chronic inflammation is now accepted to have a critical role in the onset of several diseases
as well as in vascular pathology, where macrophage transformation into foam cells
contributes in atherosclerotic plaque formation. Endothelial cells (EC) have a critical function
in recruitment of immune cells, and proinflammatory cytokines drive the specific expression
of several adhesion proteins. During inflammatory responses several cells produce
hyaluronan matrices that promote monocyte/macrophage adhesion through interactions with …