[HTML][HTML] Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England

N Andrews, J Stowe, F Kirsebom, S Toffa… - Nature medicine, 2022 - nature.com
N Andrews, J Stowe, F Kirsebom, S Toffa, R Sachdeva, C Gower, M Ramsay, J Lopez Bernal
Nature medicine, 2022nature.com
Booster vaccination with messenger RNA (mRNA) vaccines has been offered to adults in
England starting on 14 September 2021. We used a test-negative case–control design to
estimate the relative effectiveness of a booster dose of BNT162b2 (Pfizer-BioNTech)
compared to only a two-dose primary course (at least 175 days after the second dose) or
unvaccinated individuals from 13 September 2021 to 5 December 2021, when Delta variant
was dominant in circulation. Outcomes were symptomatic coronavirus disease 2019 (COVID …
Abstract
Booster vaccination with messenger RNA (mRNA) vaccines has been offered to adults in England starting on 14 September 2021. We used a test-negative case–control design to estimate the relative effectiveness of a booster dose of BNT162b2 (Pfizer-BioNTech) compared to only a two-dose primary course (at least 175 days after the second dose) or unvaccinated individuals from 13 September 2021 to 5 December 2021, when Delta variant was dominant in circulation. Outcomes were symptomatic coronavirus disease 2019 (COVID-19) and hospitalization. The relative effectiveness against symptomatic disease 14–34 days after a BNT162b2 or mRNA-1273 (Moderna) booster after a ChAdOx1-S (AstraZeneca) and BNT162b2 as a primary course ranged from around 85% to 95%. Absolute vaccine effectiveness ranged from 94% to 97% and was similar in all age groups. Limited waning was seen 10 or more weeks after the booster. Against hospitalization or death, absolute effectiveness of a BNT162b2 booster ranged from around 97% to 99% in all age groups irrespective of the primary course, with no evidence of waning up to 10 weeks. This study provides real-world evidence of substantially increased protection from the booster vaccine dose against mild and severe disease irrespective of the primary course.
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