Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count
TW Schacker, C Reilly, GJ Beilman, J Taylor, D Skarda… - Aids, 2005 - journals.lww.com
TW Schacker, C Reilly, GJ Beilman, J Taylor, D Skarda, D Krason, M Larson, AT Haase
Aids, 2005•journals.lww.comThe structure of lymphatic tissues is an important component of lymphatic tissue T-cell
homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts
the niche and limits the size of the resident CD4 cell population. In this report we show that a
single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the
peripheral CD4 cell pool with HAART (P< 0.001). This suggests that collagen-targeted
therapies might be of benefit.
homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts
the niche and limits the size of the resident CD4 cell population. In this report we show that a
single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the
peripheral CD4 cell pool with HAART (P< 0.001). This suggests that collagen-targeted
therapies might be of benefit.
Abstract
The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P< 0.001). This suggests that collagen-targeted therapies might be of benefit.
Lippincott Williams & Wilkins