Oxidative stress and antioxidants in inflammatory bowel disease
SM Karp, TR Koch - Disease-a-Month, 2006 - Elsevier
Oxidative stress in this section will refer to the availability of free radicals to react with target
tissues because of inadequate antioxidant capacity or bioavailability. One major target for
free radical reactions is the presence of unsaturated bonds in membrane phospholipids. The
consequence of this reaction is lipid peroxidation, which can result in the loss of membrane
fluidity, receptor alignment, and potentially, cellular lysis. 1 As a second target, free radical
induced damage to sulfur-containing enzymes and other proteins results in their inactivation …
tissues because of inadequate antioxidant capacity or bioavailability. One major target for
free radical reactions is the presence of unsaturated bonds in membrane phospholipids. The
consequence of this reaction is lipid peroxidation, which can result in the loss of membrane
fluidity, receptor alignment, and potentially, cellular lysis. 1 As a second target, free radical
induced damage to sulfur-containing enzymes and other proteins results in their inactivation …