OBJECTIVE: To systematically review evidence relating to the clinical efficacy of oseltamivir,
zanamivir and amantadine in the prevention of influenza. METHODS: RCTs evaluating
these interventions in seasonal prophylaxis and post-exposure prophylaxis were identified
using electronic bibliographic databases and handsearching of retrieved articles. RESULTS:
Oseltamivir was effective in preventing symptomatic laboratory-confirmed influenza (SLCI) in
seasonal prophylaxis in healthy adults and at-risk elderly subjects and in post-exposure …