Airway and systemic inflammation and decline in lung function in patients with COPD

GC Donaldson, TAR Seemungal, IS Patel, A Bhowmik… - Chest, 2005 - Elsevier
Study objectives Patients with COPD experience lower airway and systemic inflammation,
and an accelerated decline in FEV 1. There is no evidence on whether this inflammation
changes over time, or if it is associated with a faster decline in FEV 1. Patients and design A
cohort of 148 COPD patients (100 men) was monitored daily for a median of 2.91 years
(interquartile range [IQR], 2.1 to 4.8). At recruitment, median age was 68.5 years (IQR, 62.5
to 73.6) and FEV 1 as percentage of predicted (FEV 1% Pred) was 38.5%(IQR, 27.7 to 50.3) …