[HTML][HTML] Evidence for and against direct kidney infection by SARS-CoV-2 in patients with COVID-19

L Hassler, F Reyes, MA Sparks… - Clinical Journal of the …, 2021 - journals.lww.com
Despite evidence of multiorgan tropism of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in patients with coronavirus disease 2019 (COVID-19), direct viral kidney
invasion has been difficult to demonstrate. The question of whether SARS-CoV2 can directly
infect the kidney is relevant to the understanding of pathogenesis of AKI and collapsing
glomerulopathy in patients with COVID-19. Methodologies to document SARS-CoV-2
infection that have been used include immunohistochemistry, immunofluorescence, RT …