[HTML][HTML] Effects of omega-3 fatty acid in nonalcoholic fatty liver disease: a meta-analysis
W Lu, S Li, J Li, J Wang, R Zhang, Y Zhou… - … research and practice, 2016 - hindawi.com
W Lu, S Li, J Li, J Wang, R Zhang, Y Zhou, Q Yin, Y Zheng, F Wang, Y Xia, K Chen, T Liu…
Gastroenterology research and practice, 2016•hindawi.comA meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation
(n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate
aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids
(triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density
lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic
steatohepatitis (NASH). Methods. MEDLINE/PubMed, EMBASE, the Cochrane Central …
(n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate
aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids
(triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density
lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic
steatohepatitis (NASH). Methods. MEDLINE/PubMed, EMBASE, the Cochrane Central …
A meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids (triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).
Methods
MEDLINE/PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, Science Citation Index (ISI Web of Science), Chinese Biomedical Literature Database (CBM), and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant randomized controlled trials on the effects of n-3 polyunsaturated fatty acids (PUFAs) in patients with NAFLD from inception to May 2015. Ten studies were included in this meta-analysis.
Results
577 cases of NAFLD/NASH in ten randomized controlled trials (RCTs) were included. The results of the meta-analysis showed that benefit changes in liver fat favored PUFA treatment, and it was also beneficial for GGT, but it was not significant on ALT, AST, TC, and LDL.
Conclusions
In this meta-analysis, omega-3 PUFAs improved liver fat, GGT, TG, and HDL in patients with NAFLD/NASH. Therefore, n-3 PUFAs may be a new treatment option for NAFLD.
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