Immunohistochemical phenotyping of liver macrophages in normal and diseased human liver
M Tomita, K Yamamoto, H Kobashi, M Ohmoto… - Hepatology, 1994 - journals.lww.com
The phenotypical heterogeneity of human liver macrophages was analyzed with monoclonal
antibodies that recognize antigens specific for the monocytemacrophage lineage. Most liver
macrophages in normal and diseased liver were positive for CD68, whereas fewer matured
macrophages were detected by 25-F9. Comparative staining of mirror sections revealed
some to be doubly positive and others to be singly CD68 positive. Quantitative analysis
confirmed the difference, suggesting heterogeneity of maturation in liver macrophages. Most …
antibodies that recognize antigens specific for the monocytemacrophage lineage. Most liver
macrophages in normal and diseased liver were positive for CD68, whereas fewer matured
macrophages were detected by 25-F9. Comparative staining of mirror sections revealed
some to be doubly positive and others to be singly CD68 positive. Quantitative analysis
confirmed the difference, suggesting heterogeneity of maturation in liver macrophages. Most …