The multifaceted role of Notch in cardiac development and disease

FA High, JA Epstein - Nature Reviews Genetics, 2008 - nature.com
FA High, JA Epstein
Nature Reviews Genetics, 2008nature.com
Notch receptors and their cognate ligands transduce crucial signals between cells in various
tissues, and have been conserved across millions of years of evolution. Mutations in Notch
signalling components result in congenital heart defects in humans and mice, demonstrating
an essential role for Notch in cardiovascular development. The results of recent experiments
implicate this signalling pathway in many stages of heart development, and provide
mechanistic insight into the vital functions of Notch in the aetiology of several common forms …
Abstract
Notch receptors and their cognate ligands transduce crucial signals between cells in various tissues, and have been conserved across millions of years of evolution. Mutations in Notch signalling components result in congenital heart defects in humans and mice, demonstrating an essential role for Notch in cardiovascular development. The results of recent experiments implicate this signalling pathway in many stages of heart development, and provide mechanistic insight into the vital functions of Notch in the aetiology of several common forms of paediatric and adult cardiac disease.
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