Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
LJ Sundberg-Smith, JT Doherty, CP Mack… - Journal of Biological …, 2005 - jbc.org
The Rac1/Cdc42 effector p21-activated kinase (PAK) is activated by various signaling
cascades including receptor-tyrosine kinases and integrins and regulates a number of
processes such as cell proliferation and motility. PAK activity has been shown to be required
for maximal activation of the canonical Ras/Raf/MEK/ERK Map kinase signaling cascade,
likely because of PAK co-activation of Raf and MEK. Herein, we found that adhesion
signaling also stimulates an association between PAK1 and ERK1/2. PAK1 and ERK1/2 co …
cascades including receptor-tyrosine kinases and integrins and regulates a number of
processes such as cell proliferation and motility. PAK activity has been shown to be required
for maximal activation of the canonical Ras/Raf/MEK/ERK Map kinase signaling cascade,
likely because of PAK co-activation of Raf and MEK. Herein, we found that adhesion
signaling also stimulates an association between PAK1 and ERK1/2. PAK1 and ERK1/2 co …
