[HTML][HTML] The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch signaling in vascular smooth muscle cells
JM Boucher, SM Peterson, S Urs, C Zhang… - Journal of Biological …, 2011 - ASBMB
Activation of Notch signaling by Jagged-1 (Jag-1) in vascular smooth muscle cells (VSMC)
promotes a differentiated phenotype characterized by increased expression of contractile
proteins. Recent studies show that microRNAs (miR)-143/145 regulates VSMC phenotype.
The serum response factor (SRF)/myocardin complex binds to CArG sequences to activate
miR-143/145 transcription, but no other regulators are known in VSMC. Using miR arrays,
we found miR-143/145 induced following expression of a constitutively active Notch1 …
promotes a differentiated phenotype characterized by increased expression of contractile
proteins. Recent studies show that microRNAs (miR)-143/145 regulates VSMC phenotype.
The serum response factor (SRF)/myocardin complex binds to CArG sequences to activate
miR-143/145 transcription, but no other regulators are known in VSMC. Using miR arrays,
we found miR-143/145 induced following expression of a constitutively active Notch1 …