Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells
KL Du, M Chen, J Li, JJ Lepore, P Mericko… - Journal of Biological …, 2004 - jbc.org
The SAP domain transcription factor myocardin plays a critical role in the transcriptional
program regulating smooth muscle cell differentiation. In this report, we describe the
capacity of myocardin to physically associate with megakaryoblastic leukemia factor-1
(MKL1) and characterize the function of MKL1 in smooth muscle cells (SMCs). The MKL1
gene is expressed in most human tissues and myocardin and MKL are co-expressed in
SMCs. MKL1 and myocardin physically associate via conserved leucine zipper domains …
program regulating smooth muscle cell differentiation. In this report, we describe the
capacity of myocardin to physically associate with megakaryoblastic leukemia factor-1
(MKL1) and characterize the function of MKL1 in smooth muscle cells (SMCs). The MKL1
gene is expressed in most human tissues and myocardin and MKL are co-expressed in
SMCs. MKL1 and myocardin physically associate via conserved leucine zipper domains …
