Nuclear import mechanism for myocardin family members and their correlation with vascular smooth muscle cell phenotype
S Nakamura, K Hayashi, K Iwasaki, T Fujioka… - Journal of Biological …, 2010 - jbc.org
Myocardin (Mycd), which is essential for the differentiation of the smooth muscle cell lineage,
is constitutively located in the nucleus, although its family members, myocardin-related
transcription factors A and B (MRTF-A/B), mostly reside in the cytoplasm and translocate to
the nucleus in response to Rho signaling. The mechanism for their nuclear import is unclear.
Here we investigated the mechanism for the nuclear import of Mycd family members and
demonstrated any correlation between such mechanism and the phenotype of vascular …
is constitutively located in the nucleus, although its family members, myocardin-related
transcription factors A and B (MRTF-A/B), mostly reside in the cytoplasm and translocate to
the nucleus in response to Rho signaling. The mechanism for their nuclear import is unclear.
Here we investigated the mechanism for the nuclear import of Mycd family members and
demonstrated any correlation between such mechanism and the phenotype of vascular …