[HTML][HTML] Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-β and TLR ligands

BA Zabel, T Ohyama, L Zuniga, JY Kim… - Experimental …, 2006 - Elsevier
OBJECTIVE: Chemokine-like receptor 1 (CMKLR1) is expressed by human antigen
presenting cells and binds to chemerin, a proteolytically activatable chemoattractant. Here
we assessed the expression of mCMKLR1 on mouse leukocytes, focusing on ex vivo
dendritic cells (DC) and macrophages. mCMKLR1-expressing cells were evaluated for
functional responses to chemerin. We examined the regulation of mCMKLR1 expression by
exposure to toll-like receptor (TLR) ligands and cytokines. Finally, we evaluated ex vivo …