Chemerin reveals its chimeric nature
T Yoshimura, JJ Oppenheim - The Journal of experimental …, 2008 - pmc.ncbi.nlm.nih.gov
T Yoshimura, JJ Oppenheim
The Journal of experimental medicine, 2008•pmc.ncbi.nlm.nih.govChemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1
on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan
GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a
unique mechanism by which chemerin enhances inflammation. Furthermore, because
recent data shows that chemerin-derived peptides possess antiinflammatory properties,
chemerin may be involved in both the initiation and resolution of inflammation.
on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan
GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a
unique mechanism by which chemerin enhances inflammation. Furthermore, because
recent data shows that chemerin-derived peptides possess antiinflammatory properties,
chemerin may be involved in both the initiation and resolution of inflammation.
Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
pmc.ncbi.nlm.nih.gov