Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of
lung homoeostasis. In the last decade, there has been a revolution in our understanding of
how metabolism underlies key macrophage functions. While these initial observations were
made during steady state or using in vitro polarised macrophages, recent studies have
indicated that during many chronic lung diseases (CLDs), AMs adapt their metabolic profile …