Allogeneic stimulation causes transcriptional reactivation of latent murine cytomegalovirus
MR Forster, AA Bickerstaff, JJ Wang… - Transplantation …, 2009 - Elsevier
Cytomegalovirus (CMV) reactivation is a well-described complication of transplantation that
may be caused by allogeneic stimulation, immunosuppression, or both. These studies were
performed to determine if allogeneic stimulation alone is sufficient to reactivate latent CMV.
BALB/c mice latently infected with Smith strain murine CMV (MCMV) received allograft (n=
8), allograft plus cortisol (n= 5), or isograft (n= 4) skin. All allograft recipients rejected their
grafts within 9 to 12 days of transplantation. Three weeks after grafting, recipients were …
may be caused by allogeneic stimulation, immunosuppression, or both. These studies were
performed to determine if allogeneic stimulation alone is sufficient to reactivate latent CMV.
BALB/c mice latently infected with Smith strain murine CMV (MCMV) received allograft (n=
8), allograft plus cortisol (n= 5), or isograft (n= 4) skin. All allograft recipients rejected their
grafts within 9 to 12 days of transplantation. Three weeks after grafting, recipients were …