Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
JE Rossouw, RL Prentice, JAE Manson, LL Wu… - Jama, 2007 - jamanetwork.com
ContextThe timing of initiation of hormone therapy may influence its effect on cardiovascular
disease. ObjectiveTo explore whether the effects of hormone therapy on risk of
cardiovascular disease vary by age or years since menopause began. Design, Setting, and
ParticipantsSecondary analysis of the Women's Health Initiative (WHI) randomized
controlled trials of hormone therapy in which 10 739 postmenopausal women who had
undergone a hysterectomy were randomized to conjugated equine estrogens (CEE) or …
disease. ObjectiveTo explore whether the effects of hormone therapy on risk of
cardiovascular disease vary by age or years since menopause began. Design, Setting, and
ParticipantsSecondary analysis of the Women's Health Initiative (WHI) randomized
controlled trials of hormone therapy in which 10 739 postmenopausal women who had
undergone a hysterectomy were randomized to conjugated equine estrogens (CEE) or …