Sexual dimorphism and estrogen action in mouse liver
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity, 2017•Springer
Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is
expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant
for energy metabolism and drug metabolism. The sex-related differential expression of the
hepatic ERα raises the questions as to whether this receptor is responsible for the sexual
differences observed in the physiopathology of the liver.
expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant
for energy metabolism and drug metabolism. The sex-related differential expression of the
hepatic ERα raises the questions as to whether this receptor is responsible for the sexual
differences observed in the physiopathology of the liver.
Abstract
Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.
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