Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol
C Kluft, Y Zimmerman, M Mawet, C Klipping… - Contraception, 2017 - Elsevier
Objective The effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone
(DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG),
angiotensinogen and 12 hemostasis markers. Study design Combinations of 3 mg DRSP
with 5 or 10 mg E4 were compared with YAZ®(20 mcg ethinyl estradiol and 3 mg DRSP;
EE/DRSP) in parallel groups of 15–18 healthy young women. Main outcome was the relative
change from pretreatment to the end (day 24±1) of the third treatment cycle. Results All E4 …
(DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG),
angiotensinogen and 12 hemostasis markers. Study design Combinations of 3 mg DRSP
with 5 or 10 mg E4 were compared with YAZ®(20 mcg ethinyl estradiol and 3 mg DRSP;
EE/DRSP) in parallel groups of 15–18 healthy young women. Main outcome was the relative
change from pretreatment to the end (day 24±1) of the third treatment cycle. Results All E4 …