Termination of TGF-β superfamily signaling through SMAD dephosphorylation—a functional genomic view
X Lin, Y Chen, A Meng, X Feng - Journal of Genetics and Genomics, 2007 - Elsevier
The transforming growth factor-β (TGF-β) and related growth factors activate a broad range
of cellular responses in metazoan organisms via autocrine, paracrine, and endocrine
modes. They play key roles in the pathogenesis of many diseases especially cancer, fibrotic
diseases, autoimmune diseases and cardiovascular diseases. TGF-β receptor-mediated
phosphorylation of R-SMADs represents the most critical step in the TGF-β signaling
pathways that triggers a cascade of intracellular events from SMAD complex assembly in the …
of cellular responses in metazoan organisms via autocrine, paracrine, and endocrine
modes. They play key roles in the pathogenesis of many diseases especially cancer, fibrotic
diseases, autoimmune diseases and cardiovascular diseases. TGF-β receptor-mediated
phosphorylation of R-SMADs represents the most critical step in the TGF-β signaling
pathways that triggers a cascade of intracellular events from SMAD complex assembly in the …
