[HTML][HTML] Delayed re-epithelialization in Ppm1a gene-deficient mice is mediated by enhanced activation of Smad2
X Yang, Y Teng, N Hou, X Fan, X Cheng, J Li… - Journal of Biological …, 2011 - ASBMB
Protein phosphatase magnesium-dependent 1A (PPM1A), a protein serine/threonine
phosphatase, controls several signal pathways through cleavage of phosphate from its
substrates. However, the in vivo function of Ppm1a in mammals remains unknown. Here we
reported that mice lacking Ppm1a developed normally but were impaired in re-
epithelialization process during cutaneous wound healing. Specifically, complete or
keratinocyte-specific deletion of Ppm1a led to delayed re-epithelialization with reduced …
phosphatase, controls several signal pathways through cleavage of phosphate from its
substrates. However, the in vivo function of Ppm1a in mammals remains unknown. Here we
reported that mice lacking Ppm1a developed normally but were impaired in re-
epithelialization process during cutaneous wound healing. Specifically, complete or
keratinocyte-specific deletion of Ppm1a led to delayed re-epithelialization with reduced …