Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage …
ENB Davidson, EL Vitters, PM Van Der Kraan… - Annals of the rheumatic …, 2006 - Elsevier
Background: The primary feature of osteoarthritis is cartilage loss. In addition, osteophytes
can frequently be observed. Transforming growth factor-β (TGFβ) has been suggested to be
associated with protection against cartilage damage and new cartilage formation as seen in
osteophytes. Objective: To study TGFβ and TGFβ signalling in experimental osteoarthritis to
gain insight into the role of TGFβ in cartilage degradation and osteophyte formation during
osteoarthritis progression. Methods: Histological sections of murine knee joints were stained …
can frequently be observed. Transforming growth factor-β (TGFβ) has been suggested to be
associated with protection against cartilage damage and new cartilage formation as seen in
osteophytes. Objective: To study TGFβ and TGFβ signalling in experimental osteoarthritis to
gain insight into the role of TGFβ in cartilage degradation and osteophyte formation during
osteoarthritis progression. Methods: Histological sections of murine knee joints were stained …
