Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway
X Duan, YY Liang, XH Feng, X Lin - Journal of Biological Chemistry, 2006 - jbc.org
Bone morphogenetic proteins (BMPs) are secreted polypeptides belonging to the
transforming growth factor-β (TGF-β) superfamily that activates a broad range of biological
responses in the metazoan organism. The BMP-initiated signaling pathway is under tight
control by processes including regulation of the ligands, the receptors, and the key
downstream intracellular effector Smads. A critical point of control in BMP signaling is the
phosphorylation of Smad1, Smad5, and Smad8 in their C-terminal SXS motif. Although such …
transforming growth factor-β (TGF-β) superfamily that activates a broad range of biological
responses in the metazoan organism. The BMP-initiated signaling pathway is under tight
control by processes including regulation of the ligands, the receptors, and the key
downstream intracellular effector Smads. A critical point of control in BMP signaling is the
phosphorylation of Smad1, Smad5, and Smad8 in their C-terminal SXS motif. Although such …
