High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1)
A Jaitovich, M Angulo, E Lecuona, LA Dada… - Journal of Biological …, 2015 - jbc.org
Patients with chronic obstructive pulmonary disease, acute lung injury, and critical care
illness may develop hypercapnia. Many of these patients often have muscle dysfunction
which increases morbidity and impairs their quality of life. Here, we investigated whether
hypercapnia leads to skeletal muscle atrophy. Mice exposed to high CO 2 had decreased
skeletal muscle wet weight, fiber diameter, and strength. Cultured myotubes exposed to high
CO 2 had reduced fiber diameter, protein/DNA ratios, and anabolic capacity. High CO 2 …
illness may develop hypercapnia. Many of these patients often have muscle dysfunction
which increases morbidity and impairs their quality of life. Here, we investigated whether
hypercapnia leads to skeletal muscle atrophy. Mice exposed to high CO 2 had decreased
skeletal muscle wet weight, fiber diameter, and strength. Cultured myotubes exposed to high
CO 2 had reduced fiber diameter, protein/DNA ratios, and anabolic capacity. High CO 2 …