Re-examining permissive hypercapnia in ARDS: a narrative review
T Barnes, V Zochios, K Parhar - Chest, 2018 - Elsevier
Lung-protective ventilation (LPV) has become the cornerstone of management in patients
with ARDS. A subset of patients is unable to tolerate LPV without significant CO 2 elevation.
In these patients, permissive hypercapnia is used. Although thought to be benign, it is
becoming increasingly evident that elevated CO 2 levels have significant physiological
effects. In this narrative review, we highlight clinically relevant end-organ effects in both
animal models and clinical studies. We also explore the association between elevated CO 2 …
with ARDS. A subset of patients is unable to tolerate LPV without significant CO 2 elevation.
In these patients, permissive hypercapnia is used. Although thought to be benign, it is
becoming increasingly evident that elevated CO 2 levels have significant physiological
effects. In this narrative review, we highlight clinically relevant end-organ effects in both
animal models and clinical studies. We also explore the association between elevated CO 2 …
