β-Catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells
AS Flozak, AP Lam, S Russell, M Jain, ON Peled… - Journal of Biological …, 2010 - jbc.org
The Wnt/β-catenin signaling cascade activates genes that allow cells to adopt particular
identities throughout development. In adult self-renewing tissues like intestine and blood,
activation of the Wnt pathway maintains a progenitor phenotype, whereas forced inhibition of
this pathway promotes differentiation. In the lung alveolus, type 2 epithelial cells (AT2) have
been described as progenitors for the type 1 cell (AT1), but whether AT2 progenitors use the
same signaling mechanisms to control differentiation as rapidly renewing tissues is not …
identities throughout development. In adult self-renewing tissues like intestine and blood,
activation of the Wnt pathway maintains a progenitor phenotype, whereas forced inhibition of
this pathway promotes differentiation. In the lung alveolus, type 2 epithelial cells (AT2) have
been described as progenitors for the type 1 cell (AT1), but whether AT2 progenitors use the
same signaling mechanisms to control differentiation as rapidly renewing tissues is not …
