[HTML][HTML] A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous …
M Goudreault, LM D'Ambrosio, MJ Kean… - Molecular & Cellular …, 2009 - ASBMB
The serine/threonine protein phosphatases are targeted to specific subcellular locations and
substrates in part via interactions with a wide variety of regulatory proteins. Understanding
these interactions is thus critical to understanding phosphatase function. Using an iterative
affinity purification/mass spectrometry approach, we generated a high density interaction
map surrounding the protein phosphatase 2A catalytic subunit. This approach recapitulated
the assembly of the PP2A catalytic subunit into many different trimeric complexes but also …
substrates in part via interactions with a wide variety of regulatory proteins. Understanding
these interactions is thus critical to understanding phosphatase function. Using an iterative
affinity purification/mass spectrometry approach, we generated a high density interaction
map surrounding the protein phosphatase 2A catalytic subunit. This approach recapitulated
the assembly of the PP2A catalytic subunit into many different trimeric complexes but also …