Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase
S Sukhanov, P Snarski, C Vaughn, P Lobelle-Rich… - Atherosclerosis, 2015 - Elsevier
Objective: We have shown that insulin-like growth factor I (IGF-1) infusion in Apoe−/− mice
decreased atherosclerotic plaque size and plaque macrophage and lipid content suggesting
that IGF-1 suppressed formation of macrophage-derived foam cells. Since 12/15-
lipoxygenase (12/15-LOX) plays an important role in OxLDL and foam cell formation, we
hypothesized that IGF-1 downregulates 12/15-LOX, thereby suppressing lipid oxidation and
foam cell formation. Approach and Results: We found that IGF-1 decreased 12/15-LOX …
decreased atherosclerotic plaque size and plaque macrophage and lipid content suggesting
that IGF-1 suppressed formation of macrophage-derived foam cells. Since 12/15-
lipoxygenase (12/15-LOX) plays an important role in OxLDL and foam cell formation, we
hypothesized that IGF-1 downregulates 12/15-LOX, thereby suppressing lipid oxidation and
foam cell formation. Approach and Results: We found that IGF-1 decreased 12/15-LOX …