Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice
MR Schroeter, T Humboldt, K Schäfer… - Atherosclerosis, 2009 - Elsevier
Statins enhance incorporation of bone marrow-derived cells into experimental neointimal
lesions. However, the contribution of progenitor cells to progression of spontaneous
atherosclerotic plaques, and the possible modulatory role of statins in this process, remain
poorly understood. We compared the effects of rosuvastatin (1 and 10mg/kg BW) and
pravastatin (10mg/kg) on progenitor cell mobilisation, recruitment into atherosclerotic
plaques, and lesion growth. Statins were administered over 8 weeks to apolipoprotein E …
lesions. However, the contribution of progenitor cells to progression of spontaneous
atherosclerotic plaques, and the possible modulatory role of statins in this process, remain
poorly understood. We compared the effects of rosuvastatin (1 and 10mg/kg BW) and
pravastatin (10mg/kg) on progenitor cell mobilisation, recruitment into atherosclerotic
plaques, and lesion growth. Statins were administered over 8 weeks to apolipoprotein E …