Dysregulation of autoantigen genes in ANCA-associated vasculitis involves alternative transcripts and new protein synthesis
EA McInnis, AK Badhwar, A Muthigi… - Journal of the …, 2015 - journals.lww.com
Abstract Proteinase 3 (PR3) and myeloperoxidase (MPO) are two major autoantigens in
patients with vasculitis with ANCA. The genes encoding these autoantigens are abnormally
expressed in peripheral granulocytes of patients with active ANCA-associated vasculitis.
This study provides evidence that this transcriptional dysregulation results in a variety of
mRNA processing events from the PRTN3 gene locus. In addition to elevated levels of PR3
message, leukocyte RNA from patients contained PR3 transcripts with an alternative 3 …
patients with vasculitis with ANCA. The genes encoding these autoantigens are abnormally
expressed in peripheral granulocytes of patients with active ANCA-associated vasculitis.
This study provides evidence that this transcriptional dysregulation results in a variety of
mRNA processing events from the PRTN3 gene locus. In addition to elevated levels of PR3
message, leukocyte RNA from patients contained PR3 transcripts with an alternative 3 …