Immunological interaction of HLA-DPB1 and proteinase 3 in ANCA vasculitis is associated with clinical disease activity
DP Chen, EA McInnis, EY Wu… - Journal of the …, 2022 - journals.lww.com
Background PR3-ANCA vasculitis has a genetic association with HLA-DPB1. We explored
immunologic and clinical features related to the interaction of HLA-DPB1* 04: 01 with a
strongly binding PR3 peptide epitope (PR3 225–239). Methods Patients with ANCA
vasculitis with active disease and disease in remission were followed longitudinally.
Peripheral blood mononuclear cells from patients and healthy controls with HLA-DPB1* 04:
01 were tested for HLA-DPB1* 04: 01 expression and interaction with a PR3 peptide …
immunologic and clinical features related to the interaction of HLA-DPB1* 04: 01 with a
strongly binding PR3 peptide epitope (PR3 225–239). Methods Patients with ANCA
vasculitis with active disease and disease in remission were followed longitudinally.
Peripheral blood mononuclear cells from patients and healthy controls with HLA-DPB1* 04:
01 were tested for HLA-DPB1* 04: 01 expression and interaction with a PR3 peptide …