The ddY mouse: a model of postprandial hypertriglyceridemia in response to dietary fat
T Yamazaki, K Kishimoto, O Ezaki - Journal of lipid research, 2012 - ASBMB
Postprandial hyperlipidemia (lipemia) is a risk factor for atherosclerosis. However, mouse
models of postprandial hyperlipidemia have not been reported. Here, we report that ddY
mice display marked postprandial hypertriglyceridemia in response to dietary fat. In ddY
mice, the fasting serum total triacylglyceride (TG) concentration was 134 mg/dl, which
increased to 571 mg/dl after an intragastric safflower oil load (0.4 ml/mouse). In C57BL/6J
mice, these concentrations were 57 and 106 mg/dl, respectively. By lipoprotein analysis …
models of postprandial hyperlipidemia have not been reported. Here, we report that ddY
mice display marked postprandial hypertriglyceridemia in response to dietary fat. In ddY
mice, the fasting serum total triacylglyceride (TG) concentration was 134 mg/dl, which
increased to 571 mg/dl after an intragastric safflower oil load (0.4 ml/mouse). In C57BL/6J
mice, these concentrations were 57 and 106 mg/dl, respectively. By lipoprotein analysis …
