Therapeutic effects of butyrate on pediatric obesity: a randomized clinical trial
S Coppola, R Nocerino, L Paparo, G Bedogni… - JAMA Network …, 2022 - jamanetwork.com
Importance The pediatric obesity disease burden imposes the necessity of new effective
strategies. Objective To determine whether oral butyrate supplementation as an adjunct to
standard care is effective in the treatment of pediatric obesity. Design, Setting, and
Participants A randomized, quadruple-blind, placebo-controlled trial was performed from
November 1, 2020, to December 31, 2021, at the Tertiary Center for Pediatric Nutrition,
Department of Translational Medical Science, University of Naples Federico II, Naples, Italy …
strategies. Objective To determine whether oral butyrate supplementation as an adjunct to
standard care is effective in the treatment of pediatric obesity. Design, Setting, and
Participants A randomized, quadruple-blind, placebo-controlled trial was performed from
November 1, 2020, to December 31, 2021, at the Tertiary Center for Pediatric Nutrition,
Department of Translational Medical Science, University of Naples Federico II, Naples, Italy …