Ca2+/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome
T Steinkellner, JW Yang, TR Montgomery… - Journal of Biological …, 2012 - ASBMB
The dopamine transporter (DAT) is a crucial regulator of dopaminergic neurotransmission,
controlling the length and brevity of dopaminergic signaling. DAT is also the primary target of
psychostimulant drugs such as cocaine and amphetamines. Conversely, methylphenidate
and amphetamine are both used clinically in the treatment of attention-deficit hyperactivity
disorder and narcolepsy. The action of amphetamines, which induce transport reversal,
relies primarily on the ionic composition of the intra-and extracellular milieus. Recent …
controlling the length and brevity of dopaminergic signaling. DAT is also the primary target of
psychostimulant drugs such as cocaine and amphetamines. Conversely, methylphenidate
and amphetamine are both used clinically in the treatment of attention-deficit hyperactivity
disorder and narcolepsy. The action of amphetamines, which induce transport reversal,
relies primarily on the ionic composition of the intra-and extracellular milieus. Recent …
