Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat
BACKGROUND: Environmental or genetic disturbances of early brain development are
suggested to underlie the pathophysiology of several adult-onset neuropsychiatric
disorders. We traced the developmental trajectories of brain structural and behavioral
abnormalities from adolescence to young adulthood in rats born to mothers exposed to the
viral mimic polyriboinosinic-polyribocytidylic acid (poly-I: C) in pregnancy. METHODS:
Pregnant rats were injected on gestational day 15 with poly-I: C (4 mg/kg) or saline. Volumes …
suggested to underlie the pathophysiology of several adult-onset neuropsychiatric
disorders. We traced the developmental trajectories of brain structural and behavioral
abnormalities from adolescence to young adulthood in rats born to mothers exposed to the
viral mimic polyriboinosinic-polyribocytidylic acid (poly-I: C) in pregnancy. METHODS:
Pregnant rats were injected on gestational day 15 with poly-I: C (4 mg/kg) or saline. Volumes …