Salt accelerates allograft rejection through serum-and glucocorticoid-regulated Kinase-1–dependent inhibition of regulatory T cells
A high-salt diet (HSD) in humans is linked to a number of complications, including
hypertension and cardiovascular events. Whether a HSD affects the immune response in
transplantation is unknown. Using a murine transplantation model, we investigated the effect
of NaCl on the alloimmune response in vitro and in vivo. Incremental NaCl concentrations in
vitro augmented T cell proliferation in the settings of both polyclonal and allospecific
stimulation. Feeding a HSD to C57BL/6 wild-type recipients of bm12 allografts led to …
hypertension and cardiovascular events. Whether a HSD affects the immune response in
transplantation is unknown. Using a murine transplantation model, we investigated the effect
of NaCl on the alloimmune response in vitro and in vivo. Incremental NaCl concentrations in
vitro augmented T cell proliferation in the settings of both polyclonal and allospecific
stimulation. Feeding a HSD to C57BL/6 wild-type recipients of bm12 allografts led to …