Mitochondria in acute kidney injury
KM Ralto, SM Parikh - Seminars in nephrology, 2016 - Elsevier
Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and
health care expenditure. In the United States alone, it is estimated that more than $10 billion
is spent on AKI every year. Currently, there are no available therapies to treat established
AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the
primary source of energy for each cell and as a key regulator of cell death. This review aims
to cover the current state of research on the role of mitochondria in AKI, while also proposing …
health care expenditure. In the United States alone, it is estimated that more than $10 billion
is spent on AKI every year. Currently, there are no available therapies to treat established
AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the
primary source of energy for each cell and as a key regulator of cell death. This review aims
to cover the current state of research on the role of mitochondria in AKI, while also proposing …