Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function
not only impact on cellular metabolism but also critically influence whole-body metabolism,
health, and life span. Diseases defined by mitochondrial dysfunction have expanded from
rare monogenic disorders in a strict sense to now also include many common polygenic
diseases, including metabolic, cardiovascular, neurodegenerative, and neuromuscular …