A mild topical steroid leads to progressive anti-inflammatory effects in the skin of patients with moderate-to-severe atopic dermatitis
PM Brunner, S Khattri, S Garcet, R Finney… - Journal of Allergy and …, 2016 - Elsevier
Background Topical glucocorticosteroids are considered an efficient treatment option for
atopic dermatitis (AD), but a global assessment of glucocorticosteroid responses on key
disease circuits upon weeks to months of treatment is currently lacking. Objective We sought
to assess short (4 weeks) and long-term (16 weeks) application of topical
glucocorticosteroids on AD skin and define response biomarkers. Methods The effects of
triamcinolone acetonide cream 0.025% were assessed based on gene expression and …
atopic dermatitis (AD), but a global assessment of glucocorticosteroid responses on key
disease circuits upon weeks to months of treatment is currently lacking. Objective We sought
to assess short (4 weeks) and long-term (16 weeks) application of topical
glucocorticosteroids on AD skin and define response biomarkers. Methods The effects of
triamcinolone acetonide cream 0.025% were assessed based on gene expression and …
