Objective Atopic dermatitis often precedes the development of other atopic diseases, and
the atopic march describes this temporal relationship in the natural history of these diseases.
Although the pathophysiological mechanisms that underlie this relationship are poorly
understood, epidemiologic and genetic data have suggested that the skin might be an
important route of sensitization to allergens. Data Sources Review of recent studies on the
role of skin barrier defects in systemic allergen sensitization. Study Selections Recent …