CXCR6 gene characterization in two ethnically distinct South African populations and association with viraemic disease control in HIV-1-infected black South African …
ACP Picton, M Paximadis, RE Chaisson… - Clinical …, 2017 - Elsevier
CXCR6 genetic variation was described for HIV-1-uninfected black (n= 41) and Caucasian
(n= 40) South Africans. We also investigated the CXCR6 rs2234358 and rs2234355 single
nucleotide polymorphisms in HIV-1 disease control in 124 HIV-1-infected drug-naïve black
individuals [elite controllers (n= 11), viraemic controllers (VCs, n= 30), high viral load long-
term nonprogressors (HVL LTNPs, n= 11) and progressors (n= 72)] compared to healthy
controls (HCs; n= 232). The rs2234358-T allele was underrepresented in VCs (40.0%) …
(n= 40) South Africans. We also investigated the CXCR6 rs2234358 and rs2234355 single
nucleotide polymorphisms in HIV-1 disease control in 124 HIV-1-infected drug-naïve black
individuals [elite controllers (n= 11), viraemic controllers (VCs, n= 30), high viral load long-
term nonprogressors (HVL LTNPs, n= 11) and progressors (n= 72)] compared to healthy
controls (HCs; n= 232). The rs2234358-T allele was underrepresented in VCs (40.0%) …