Early Antiretroviral Therapy in South African Children Reduces HIV-1–Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells
GU van Zyl, MA Bedison… - The Journal of …, 2015 - academic.oup.com
The Journal of infectious diseases, 2015•academic.oup.com
We measured cell-associated human immunodeficiency virus (HIV)-1 DNA (CAD) and RNA
(CAR) and plasma HIV-1 RNA in blood samples from 20 children in the Children with HIV
Early Antiretroviral (CHER) cohort after 7–8 years of suppressive combination antiretroviral
therapy (cART). Children who initiated cART early (< 2 months; n= 12) had lower HIV-1 CAD
(median, 48 vs 216; P<. 01) and CAR (median, 5 vs 436; P<. 01) per million peripheral blood
mononuclear cells than children who started later (≥ 2 months; n= 8). Plasma HIV-1 RNA …
(CAR) and plasma HIV-1 RNA in blood samples from 20 children in the Children with HIV
Early Antiretroviral (CHER) cohort after 7–8 years of suppressive combination antiretroviral
therapy (cART). Children who initiated cART early (< 2 months; n= 12) had lower HIV-1 CAD
(median, 48 vs 216; P<. 01) and CAR (median, 5 vs 436; P<. 01) per million peripheral blood
mononuclear cells than children who started later (≥ 2 months; n= 8). Plasma HIV-1 RNA …
Abstract
We measured cell-associated human immunodeficiency virus (HIV)-1 DNA (CAD) and RNA (CAR) and plasma HIV-1 RNA in blood samples from 20 children in the Children with HIV Early Antiretroviral (CHER) cohort after 7–8 years of suppressive combination antiretroviral therapy (cART). Children who initiated cART early (<2 months; n = 12) had lower HIV-1 CAD (median, 48 vs 216; P < .01) and CAR (median, 5 vs 436; P < .01) per million peripheral blood mononuclear cells than children who started later (≥2 months; n = 8). Plasma HIV-1 RNA levels were not significantly lower in early-treated children (0.5 vs 1.2 copies/mL; P = .16). Early treatment at <2 months of age reduces the number of HIV-infected cells and HIV CAR.
Oxford University Press