Chronic high-fat diet affects intestinal fat absorption and postprandial triglyceride levels in the mouse
The effects of chronic fat overconsumption on intestinal physiology and lipid metabolism
remain elusive. It is unknown whether a fat-mediated adaptation to lipid absorption takes
place. To address this issue, mice fed a high-fat diet (40%, w/w) were refed or not a control
diet (3%, w/w) for 3 additive weeks. Despite daily lipid intake 7.7-fold higher than in controls,
fecal lipid output remained unchanged in mice fed the triglyceride (TG)-rich diet. In situ
isolated jejunal loops revealed greater [1-14 C] linoleic acid uptake without TG accumulation …
remain elusive. It is unknown whether a fat-mediated adaptation to lipid absorption takes
place. To address this issue, mice fed a high-fat diet (40%, w/w) were refed or not a control
diet (3%, w/w) for 3 additive weeks. Despite daily lipid intake 7.7-fold higher than in controls,
fecal lipid output remained unchanged in mice fed the triglyceride (TG)-rich diet. In situ
isolated jejunal loops revealed greater [1-14 C] linoleic acid uptake without TG accumulation …
