Regulation and functions of the IL-10 family of cytokines in inflammation and disease
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family
cytokines emerged before the adaptive immune response. These cytokines elicit diverse
host defense mechanisms, especially from epithelial cells, during various infections. IL-10
family cytokines are essential for maintaining the integrity and homeostasis of tissue
epithelial layers. Members of this family can promote innate immune responses from tissue …
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family
cytokines emerged before the adaptive immune response. These cytokines elicit diverse
host defense mechanisms, especially from epithelial cells, during various infections. IL-10
family cytokines are essential for maintaining the integrity and homeostasis of tissue
epithelial layers. Members of this family can promote innate immune responses from tissue …
