HIV protease inhibitors increase TNF-α and IL-6 expression in macrophages: Involvement of the RNA-binding protein HuR
H Zhou, S Jarujaron, EC Gurley, L Chen, H Ding… - Atherosclerosis, 2007 - Elsevier
HIV protease inhibitors (PIs) have been associated with the serious Metabolic Syndrome,
which is the major risk factor of atherosclerotic cardiovascular disease. Atherosclerosis is
widely considered to be a chronic inflammatory disease. Macrophages are the most
prominent cell type present in atherosclerotic lesions and play essential roles in both early
lesion development and late lesion complications. We previously reported that HIV PIs
induced accumulation of intracellular free cholesterol and lipids, decreased endoplasmic …
which is the major risk factor of atherosclerotic cardiovascular disease. Atherosclerosis is
widely considered to be a chronic inflammatory disease. Macrophages are the most
prominent cell type present in atherosclerotic lesions and play essential roles in both early
lesion development and late lesion complications. We previously reported that HIV PIs
induced accumulation of intracellular free cholesterol and lipids, decreased endoplasmic …