The highways and byways of mRNA decay
NL Garneau, J Wilusz, CJ Wilusz - Nature reviews Molecular cell …, 2007 - nature.com
NL Garneau, J Wilusz, CJ Wilusz
Nature reviews Molecular cell biology, 2007•nature.comWhen considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay
has become difficult to ignore. Large-scale analyses indicate that as many as half of all
changes in the amounts of mRNA in some responses can be attributed to altered rates of
decay. In this article, we discuss some of the mechanisms that are used by the cell to
mediate and regulate this intriguing process.
transcriptional regulation. Recently, however, the large contribution made by mRNA decay
has become difficult to ignore. Large-scale analyses indicate that as many as half of all
changes in the amounts of mRNA in some responses can be attributed to altered rates of
decay. In this article, we discuss some of the mechanisms that are used by the cell to
mediate and regulate this intriguing process.
Abstract
When considering the control of gene expression, the focus has traditionally been on transcriptional regulation. Recently, however, the large contribution made by mRNA decay has become difficult to ignore. Large-scale analyses indicate that as many as half of all changes in the amounts of mRNA in some responses can be attributed to altered rates of decay. In this article, we discuss some of the mechanisms that are used by the cell to mediate and regulate this intriguing process.
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