Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features
Background & Aims The hepatocyte Notch pathway is a pathogenic factor in non-alcoholic
steatohepatitis (NASH)-associated fibrosis, but its role in hepatocellular carcinoma (HCC) is
less well defined. Herein, we aimed to characterize the molecular and clinical features of
Notch-active human HCC, and to investigate the mechanisms by which Notch affects NASH-
driven HCC. Methods Using a 14-gene Notch score, we stratified human HCCs from multiple
comprehensively profiled datasets. We performed gene set enrichment analyses to compare …
steatohepatitis (NASH)-associated fibrosis, but its role in hepatocellular carcinoma (HCC) is
less well defined. Herein, we aimed to characterize the molecular and clinical features of
Notch-active human HCC, and to investigate the mechanisms by which Notch affects NASH-
driven HCC. Methods Using a 14-gene Notch score, we stratified human HCCs from multiple
comprehensively profiled datasets. We performed gene set enrichment analyses to compare …