[HTML][HTML] Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem …
Q Luo, Q Kang, W Si, W Jiang, JK Park, Y Peng… - Journal of Biological …, 2004 - ASBMB
Osteoblast lineage-specific differentiation of mesenchymal stem cells is a well regulated but
poorly understood process. Both bone morphogenetic proteins (BMPs) and Wnt signaling
are implicated in regulating osteoblast differentiation and bone formation. Here we analyzed
the expression profiles of mesenchymal stem cells stimulated with Wnt3A and osteogenic
BMPs, and we identified connective tissue growth factor (CTGF) as a potential target of Wnt
and BMP signaling. We confirmed the microarray results, and we demonstrated that CTGF …
poorly understood process. Both bone morphogenetic proteins (BMPs) and Wnt signaling
are implicated in regulating osteoblast differentiation and bone formation. Here we analyzed
the expression profiles of mesenchymal stem cells stimulated with Wnt3A and osteogenic
BMPs, and we identified connective tissue growth factor (CTGF) as a potential target of Wnt
and BMP signaling. We confirmed the microarray results, and we demonstrated that CTGF …